Tailwind simplifies CSS and takes the pain out of layout to the point where you don't need someone who lives and breathes CSS to stop it breaking.
It took me ages to get into it though, perhaps because I hate CSS so much:
I won't go into how to use it ( tailwind do an excellent job of that themselves ) but suffice to say that sticking to a handful of good classes that just work is a simplification that I am now 100% behind.
In a bid to actually separate content and layout Pullnote is a headless CMS that allows users to only write markdown (like Reddit) leaving the styling to whatever front-end you're running, with basic Tailwind support for the essential content tweaks.
Download the code for this blog from GitHub at https://github.com/webuildsociety/svelte-headless